Therapy management is a critical clinical process that involves a variety of procedures (drugs, transfusions, medications,..), different professionals, a number of pr otocols, and medical instruments. It is an “error prone” process and mistakes may lead to harsh consequences. In this scenario ICTs become essential for support and governance. Nowadays beds ide activities are still of ten managed manually and literature shows that processes are managed differe ntly and supported by paper or local IT tools. Challenges are: secure patient and item identification, comprehensive information delivery to clinicians, traceability and control of costs. Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (Italy) and partner Fondazione Politecnico di Milano follow an unified approach addressing in an integrated framework processes, organization and ICT tools. This paper will describe the case of a num ber of projects done to bring safety features to bedside using Mobile&Wireless (M&W ) technologies, and RFId above all. Starting with transfusion traceability, further projects concern safety of ph armacotherapy, radiotherapy and stem cells therapy treatments. Mobile&Wireless solution scenarios, impact s and benefits will be discussed in depth: RFId emerges as a key element to close the bedside safety loop, filling the gap left by traditional hospital information systems and M&W applications.